The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.k

Sarcoid-like granulomatosis (endo-/extrathoracic)

Publications

Marcoval J, Moreno-Vílchez C, Llobera-Ris C, Torrecilla-Vall-Llossera C, Penín RM

Sarcoidosis Induced by Atezolizumab Presenting With Xanthelasma Infiltration.

The American Journal of dermatopathology. 2021;43(12):980-983

Lafon M, Blaye C, Kind M, Bechade D, Chassaigne F, Italiano A, Grellety T

Sarcoidosis-like reaction in metastatic triple negative breast cancer treated by anti-PD-L1.

The breast journal. 2019;25(5):971-973

Mitchell MA, Hogan K, Amjadi K

Atezolizumab-induced sarcoid-like granulomatous reaction in a patient with urothelial cell carcinoma.

Immunotherapy. 2018;10(14):1189-1192