The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLV.b

Eosinophilic pleural effusion

Publications

Patel JJ, Lisi PA, Lathara Z, Lipchik RJ

Clozapine-induced peripheral and pleural fluid eosinophilia.

The Annals of pharmacotherapy 2012 Feb;46;e4 — 2012 Feb — e4

Thompson J, Chengappa KN, Good CB, Baker RW, Kiewe RP, Bezner J, Schooler NR

Hepatitis, hyperglycemia, pleural effusion, eosinophilia, hematuria and proteinuria occurring early in clozapine treatment.

International clinical psychopharmacology 1998 Mar;13;95-8 — 1998 Mar — 95-8

Chatterjee A, Safferman AZ

Cellulitis, eosinophilia, and unilateral pleural effusion associated with clozapine treatment.

Journal of clinical psychopharmacology 1997 Jun;17;232-3 — 1997 Jun — 232-3