The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (interstitial lung disease/ILD)

Publications

Vaselli NM, Du Preez S, Jasenthu Kankanamage N

Clozapine-induced pneumonitis mimicking an atypical pneumonia.

BMJ case reports 2024 Mar 25;17; — 2024 Mar 25

Arias SA, Cohen P, Kwon JS

Clozapine-induced lymphocytic alveolitis.

The American journal of psychiatry 2011 Feb;168;210-1 — 2011 Feb — 210-1

Benning TB

Clozapine-induced extrinsic allergic alveolitis.

The British journal of psychiatry : the journal of mental science 1998 Nov;173;440-1 — 1998 Nov — 440-1