The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LI.g

Cardiomyopathy (acute, subacute, chronic)

In one case (PMID 26664756) left ventricular thrombus was present

Publications

Im JP, Pellegrini JR, Munshi R, Rankov L, Makaryus AN

"My Heart Said It's Swollen": A Rare Case of Clozapine-Induced Myocarditis in a Schizophrenic Patient.

Cureus 2021 May 22;13;e15168 — 2021 May 22 — e15168

Malik SA, Malik S, Dowsley TF, Singh B

Left Ventricular Thrombus as a Complication of Clozapine-Induced Cardiomyopathy: A Case Report and Brief Literature Review.

Case reports in cardiology 2015;2015;835952 — 2015 — 835952

Makhoul B, Hochberg I, Rispler S, Azzam ZS

Dilated cardiomyopathy: an unusual complication of clozapine therapy.

Nature clinical practice. Cardiovascular medicine 2008 Sep;5;566-70 — 2008 Sep — 566-70