The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLVI.a

Pulmonary embolism - Venous thrombosis/thromboembolism

Publications

Sarvaiya N, Lapitskaya Y, Dima L, Manu P

Clozapine-Associated Pulmonary Embolism: A High-Mortality, Dose-Independent and Early-Onset Adverse Effect.

American journal of therapeutics 2018 Jul/Aug;25;e434-e438 — 2018 Jul/Aug — e434-e438

Munoli RN, Praharaj SK, Bhat SM

Clozapine-induced recurrent pulmonary thromboembolism.

The Journal of neuropsychiatry and clinical neurosciences 2013;25;E50-1 — 2013 — E50-1

Joksovic PM, Chiles C

A case of cardiac arrest and pulmonary embolism after clozapine titration.

The primary care companion for CNS disorders 2011;13; — 2011

Tripp AC

Nonfatal pulmonary embolus associated with clozapine treatment: a case series.

General hospital psychiatry 2011 Jan-Feb;33;85.e5-6 — 2011 Jan-Feb — 85.e5-6

Srihari VH, Lee TW

Pulmonary embolism in a patient taking clozapine.

BMJ (Clinical research ed.) 2008 Jun 28;336;1499-501 — 2008 Jun 28 — 1499-501

Yang TY, Chung KJ, Huang TL, Kung CT

Massive pulmonary embolism in a young patient on clozapine therapy.

The Journal of emergency medicine 2004 Jul;27;27-9 — 2004 Jul — 27-9

Pan R, John V, Hägg S

Clozapine and pulmonary embolism.

Acta psychiatrica Scandinavica 2003 Jul;108;76-7; discussion 77 — 2003 Jul — 76-7; discussion 77

Coodin S, Ballegeer T

Clozapine therapy and pulmonary embolism.

Canadian journal of psychiatry. Revue canadienne de psychiatrie 2000 May;45;395 — 2000 May — 395

Hägg S, Spigset O, Söderström TG

Association of venous thromboembolism and clozapine.

Lancet (London, England) 2000 Apr 01;355;1155-6 — 2000 Apr 01 — 1155-6

Lilleng P, Morild I, Hope M

[Clozapine and myocarditis].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 1995 Oct 10;115;3026-7 — 1995 Oct 10 — 3026-7