The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Pulmonary embolism - Venous thrombosis/thromboembolism
Publications
Clozapine-Associated Pulmonary Embolism: A High-Mortality, Dose-Independent and Early-Onset Adverse Effect.
American journal of therapeutics. 2018;25(4):e434-e438
Clozapine-induced recurrent pulmonary thromboembolism.
The Journal of neuropsychiatry and clinical neurosciences. 2013;25(3):E50-1
A case of cardiac arrest and pulmonary embolism after clozapine titration.
The primary care companion for CNS disorders. 2011;13(2)
Nonfatal pulmonary embolus associated with clozapine treatment: a case series.
General hospital psychiatry. 2011;33(1):85.e5-6
Pulmonary embolism in a patient taking clozapine.
BMJ (Clinical research ed.). 2008;336(7659):1499-501
Massive pulmonary embolism in a young patient on clozapine therapy.
The Journal of emergency medicine. 2004;27(1):27-9
Clozapine and pulmonary embolism.
Acta psychiatrica Scandinavica. 2003;108(1):76-7; discussion 77
Clozapine therapy and pulmonary embolism.
Canadian journal of psychiatry. Revue canadienne de psychiatrie. 2000;45(4):395
Association of venous thromboembolism and clozapine.
Lancet (London, England). 2000;355(9210):1155-6
[Clozapine and myocarditis].
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke. 1995;115(24):3026-7