The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLV.a

Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

Publications

Patel JJ, Lisi PA, Lathara Z, Lipchik RJ

Clozapine-induced peripheral and pleural fluid eosinophilia.

The Annals of pharmacotherapy 2012 Feb;46;e4 — 2012 Feb — e4

Hauben M

Comment: papular rash and bilateral pleural effusion associated with clozapine.

The Annals of pharmacotherapy 1999 Dec;33;1374 — 1999 Dec — 1374

Stanislav SW, Gonzalez-Blanco M

Papular rash and bilateral pleural effusion associated with clozapine.

The Annals of pharmacotherapy 1999 Sep;33;1008-9 — 1999 Sep — 1008-9