The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VI.m

Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)

Publications

Kikuchi K, Yasui-Furukori N, Yokoyama S, Hasegawa C, Kokubun A, Katsukura S, Shimizu T, Shimoda K

Clozapine-associated severe eosinophilia following lithium rebound neutropenia: A case report.

Neuropsychopharmacology reports 2020 Sep 19;; — 2020 Sep 19

Waller H, Porter R, Ritz S, Beckert L

Late occurrence of clozapine-associated polyserositis.

The international journal of neuropsychopharmacology 2007 Feb;10;147-8 — 2007 Feb — 147-8

Bhatti MA, Zander J, Reeve E

Clozapine-induced pericarditis, pericardial tamponade, polyserositis, and rash.

The Journal of clinical psychiatry 2005 Nov;66;1490-1 — 2005 Nov — 1490-1

Eymin G, Andresen M, Godoy J, Rada G

[Malignant neuroleptic syndrome and polyserositis associated to clozapine use: report of one case].

Revista medica de Chile 2005 Oct;133;1225-8 — 2005 Oct — 1225-8

Branik E, Nitschke M

Pericarditis and polyserositis as a side effect of clozapine in an adolescent girl.

Journal of child and adolescent psychopharmacology 2004;14;311-4 — 2004 — 311-4

Boot E, de Haan L, Guzelcan Y, Scholte WF, Assies H

Pericardial and bilateral pleural effusion associated with clozapine treatment.

European psychiatry : the journal of the Association of European Psychiatrists 2004 Feb;19;65 — 2004 Feb — 65

Lim A, Sivakumaran P, Israel M

Clozapine-associated polyserositis.

The New Zealand medical journal 2003 Oct 24;116;U651 — 2003 Oct 24 — U651

Schonfeldt-Lecuona C, Connemann BJ

Sweet's syndrome and polyserositis with clozapine.

The American journal of psychiatry 2002 Nov;159;1947 — 2002 Nov — 1947

Malhotra S, Franco K, Tomford JW, Iqbal R

Polyserositis, acute withdrawal, and relapse after abrupt clozapine discontinuation.

Psychosomatics 2002 Sep-Oct;43;418-20 — 2002 Sep-Oct — 418-20

Catalano G, Catalano MC, Frankel Wetter RL

Clozapine induced polyserositis.

Clinical neuropharmacology 1997 Aug;20;352-6 — 1997 Aug — 352-6

Daly JM, Goldberg RJ, Braman SS

Polyserositis associated with clozapine treatment.

The American journal of psychiatry 1992 Sep;149;1274-5 — 1992 Sep — 1274-5