The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

V.m

Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)

Publications

Kikuchi K, Yasui-Furukori N, Yokoyama S, Hasegawa C, Kokubun A, Katsukura S, Shimizu T, Shimoda K

Clozapine-associated severe eosinophilia following lithium rebound neutropenia: A case report.

Neuropsychopharmacology reports. 2020;40(4):388-391

Waller H, Porter R, Ritz S, Beckert L

Late occurrence of clozapine-associated polyserositis.

The international journal of neuropsychopharmacology. 2007;10(1):147-8

Bhatti MA, Zander J, Reeve E

Clozapine-induced pericarditis, pericardial tamponade, polyserositis, and rash.

The Journal of clinical psychiatry. 2005;66(11):1490-1

Eymin G, Andresen M, Godoy J, Rada G

[Malignant neuroleptic syndrome and polyserositis associated to clozapine use: report of one case].

Revista medica de Chile. 2005;133(10):1225-8

Branik E, Nitschke M

Pericarditis and polyserositis as a side effect of clozapine in an adolescent girl.

Journal of child and adolescent psychopharmacology. 2004;14(2):311-4

Boot E, de Haan L, Guzelcan Y, Scholte WF, Assies H

Pericardial and bilateral pleural effusion associated with clozapine treatment.

European psychiatry : the journal of the Association of European Psychiatrists. 2004;19(1):65

Lim A, Sivakumaran P, Israel M

Clozapine-associated polyserositis.

The New Zealand medical journal. 2003;116(1184):U651

Schonfeldt-Lecuona C, Connemann BJ

Sweet's syndrome and polyserositis with clozapine.

The American journal of psychiatry. 2002;159(11):1947

Malhotra S, Franco K, Tomford JW, Iqbal R

Polyserositis, acute withdrawal, and relapse after abrupt clozapine discontinuation.

Psychosomatics. 2002;43(5):418-20

Catalano G, Catalano MC, Frankel Wetter RL

Clozapine induced polyserositis.

Clinical neuropharmacology. 1997;20(4):352-6

Daly JM, Goldberg RJ, Braman SS

Polyserositis associated with clozapine treatment.

The American journal of psychiatry. 1992;149(9):1274-5