The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

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Coronary artery disease (acute) - Myocardial ischemia/infarction

Publications

Henry D, Rudzik F, Butts A, Mathew A

Capecitabine-Induced Coronary Vasospasm.

Case reports in oncology 2016 Sep-Dec;9;629-632 — 2016 Sep-Dec — 629-632

Güvenç TS, Celiker E, Ozcan KS, Ilhan E, Eren M

Acute myocardial infarction after capecitabine treatment: not always vasospasm is responsible.

Chinese medical journal 2012 Sep;125;3349-51 — 2012 Sep — 3349-51

Ambrosy AP, Kunz PL, Fisher GA, Witteles RM

Capecitabine-induced chest pain relieved by diltiazem.

The American journal of cardiology 2012 Dec 01;110;1623-6 — 2012 Dec 01 — 1623-6