The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XII.a

Left or biventricular dysfunction/failure

Publications

Bini I, Asaftei SD, Riggi C, Tirtei E, Manicone R, Biasin E, Basso ME, Agnoletti G, Fagioli F

Anthracycline-induced cardiotoxicity in patients with paediatric bone sarcoma and soft tissue sarcoma.

Cardiology in the young. 2017;27(9):1815-1822

Hayek ER, Speakman E, Rehmus E

Acute doxorubicin cardiotoxicity.

The New England journal of medicine. 2005;352(23):2456-7

Singal PK, Iliskovic N

Doxorubicin-induced cardiomyopathy.

The New England journal of medicine. 1998;339(13):900-5