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The Drug-Induced Respiratory Disease Website and App

I.o

I - Interstitial/parenchymal lung disease

Focal/localized area of pneumonitis/fibrosis

Last update 11/09/2026

(Fr: fibrose pulmonaire localisée). A typical reaction to radiation therapy that is usually confined to the radiation field. May occur following radiation to the chest, or breast.. May occur as a complication of a few drugs

Causative drugs

8

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

Cyberknife ablation radiation therapy
I.o
I.ab
VIII.ab
Pembrolizumab
I.a
I.b
I.c
I.d
I.f
I.m
I.o
I.y
I.ad
II.b
III.h
III.l
IV.a
IV.c
IV.d
IV.j
IV.k
IV.n
IV.t
IV.y
IV.ab
IV.ac
IV.ad
IV.al
V.m
VI.a
VI.b
VII.a
VII.e
VIII.q
VIII.t
IX.r
X.b
X.c
X.d
X.f
X.g
X.j
X.k
X.m
X.s
X.ah
X.an
X.aw
X.ax
X.ay
X.bi
XI.d
XI.k
XII.a
XII.c
XII.d
XII.r
XII.s
XV.a
XV.b
XV.c
XV.d
XV.e
XV.f
XV.x
XV.bb
XV.ca
XV.cw
XVI.b
XVI.e
XVI.k
XVI.v
XVI.z
XVI.ai
XVII.c
XVII.g
XVII.o
XIX.a
XIX.b
Proton beam therapy
I.g
I.o
XXVII.a
XXVII.f
Radiation therapy (medium term & late effects)
I.c
I.d
I.g
I.h
I.o
I.v
I.x
II.b
III.c
IV.k
IV.m
V.a
V.b
V.c
V.f
V.h
V.l
V.m
V.t
VI.c
VI.t
VI.ab
VII.d
VII.i
VII.j
VII.l
VIII.c
VIII.j
VIII.r
VIII.t
VIII.ab
VIII.au
VIII.av
IX.a
IX.aj
XI.g
XI.l
XI.r
XI.ac
XI.av
XI.bk
XII.a
XII.b
XII.f
XII.g
XII.k
XII.o
XII.s
XII.ad
XII.ak
XII.an
XII.bc
XII.bz
XIII.a
XIII.d
XIII.e
XIII.j
XIII.l
XIII.m
XV.f
XV.l
XVI.ab
XVI.bi
XVI.bj
XVI.bl
XXVII.a
XXVII.b
XXVII.e
Radiation therapy to the breast
I.b
I.c
I.d
I.h
I.o
I.u
I.v
I.z
V.t
XII.b
XII.c
XII.o
XIII.a
XIII.m
XV.c
XVI.i
XIX.a
Radiation therapy to the chest
I.a
I.b
I.c
I.d
I.g
I.h
I.k
I.l
I.o
I.v
I.x
I.y
II.b
III.h
IV.m
V.a
V.c
V.f
V.h
V.k
VI.c
VI.x
VII.d
VIII.c
VIII.r
VIII.t
VIII.ab
VIII.au
IX.j
XI.b
XI.s
XI.ac
XII.b
XII.k
XII.o
XII.s
XIII.e
XV.c
XV.f
XV.h
XV.i
XV.bm
XVI.bl
XVII.e
XVII.af
XIX.a
XXVII.a
XXVII.b
XXVII.c
Radiation therapy, infusional (injected 131I or 90Y radioactivity)
I.b
I.o
I.w
I.ab
I.ac
II.b
V.a
XV.i
Radioactive seeds
I.o
XVI.aw