The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Myopathy-Myositis-Polymyositis (see also under Xba)
May lead to acute respiratory failure
Publications
Pembrolizumab induced bulbar myopathy and respiratory failure with necrotizing myositis of the diaphragm.
Annals of oncology : official journal of the European Society for Medical Oncology 2017 03 01;28;673-675 — 2017 03 01 — 673-675