The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

May progress to full-blown ARDS

Publications

Arpin D, Mahé MA, Servois V, Claude L

[Predictive factors for acute radiation pneumonitis].

Revue de pneumologie clinique 2009 Jun;65;177-86 — 2009 Jun — 177-86

Nieder C, Jeremic B, Astner S, Molls M

Radiotherapy-induced lung toxicity: risk factors and prevention strategies.

Anticancer research 2003 Nov-Dec;23;4991-8 — 2003 Nov-Dec — 4991-8

Goldman AL, Enquist R

Hyperacute radiation pneumonitis.

Chest 1975 May;67;613-5 — 1975 May — 613-5