The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Tracheal/large airway necrosis, chondronecrosis, perforation
Publications
Radiation-associated airway necrosis.
The Ochsner journal 2013;13;273-5 — 2013 — 273-5
Nontraumatic disruption of the fibrocartilaginous trachea: causes and clinical outcomes.
Chest 2006 Oct;130;1143-9 — 2006 Oct — 1143-9
Aspiration diseases: findings, pitfalls, and differential diagnosis.
Radiographics : a review publication of the Radiological Society of North America, Inc 2000 May-Jun;20;673-85 — 2000 May-Jun — 673-85