The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LI.a

Left or biventricular dysfunction/failure

Publications

Inayat F, Masab M, Gupta S, Ullah W

New drugs and new toxicities: pembrolizumab-induced myocarditis.

BMJ case reports 2018 Jan 23;2018; — 2018 Jan 23

Läubli H, Balmelli C, Bossard M, Pfister O, Glatz K, Zippelius A

Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma.

Journal for immunotherapy of cancer 2015;3;11 — 2015 — 11