The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.e

Organizing pneumonia pattern (an area or areas of consolidation on imaging)

Publications

Walti CS, Cheng GS, Gopal AK, Hill JA

Progressive Pulmonary Infiltrates in a Man with Mediastinal Lymphoma.

Annals of the American Thoracic Society 2021 05;18;884-888 — 2021 05 — 884-888

Shea M, Rangachari D, Hallowell RW, Hollie NI, Costa DB, VanderLaan PA

Radiologic and autopsy findings in a case of fatal immune checkpoint inhibitor-associated pneumonitis.

Cancer treatment and research communications 2018;15;17-20 — 2018 — 17-20

Ortega Sanchez G, Jahn K, Savic S, Zippelius A, Läubli H

Treatment of mycophenolate-resistant immune-related organizing pneumonia with infliximab.

Journal for immunotherapy of cancer 2018 09 03;6;85 — 2018 09 03 — 85