The Drug-Induced Respiratory Disease Website and App

Radiation therapy (medium term & late effects)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LI.b

Valvular heart disease and/or dysfunction

Review at PMID 24092234

Publications

Parkhomenko RA, Shcherbenko OI, Rybakova MK, Zelinskaya NI, Kharchenko NV, Kunda MA, Zapirov GM

Changes of the Heart Valves in the Long Term After Chemoradiotherapy According to Different Protocols for Hodgkin's Lymphoma in Children and Adolescents.

Journal of adolescent and young adult oncology 2019 Apr 24;; — 2019 Apr 24

Cella L, Oh JH, Deasy JO, Palma G, Liuzzi R, D'avino V, Conson M, Picardi M, Salvatore M, Pacelli R

Predicting radiation-induced valvular heart damage.

Acta oncologica (Stockholm, Sweden) 2015 Nov;54;1796-804 — 2015 Nov — 1796-804

Desai MY, Karunakaravel K, Wu W, Agarwal S, Smedira NG, Lytle BW, Griffin BP

Pulmonary fibrosis on multidetector computed tomography and mortality in patients with radiation-associated cardiac disease undergoing cardiac surgery.

The Journal of thoracic and cardiovascular surgery 2014 Aug;148;475-81.e3 — 2014 Aug — 475-81.e3

Cozzarín A, Cianciulli TF, Saccheri MC, Lax JA, Simonetti ME, Zappi A, Laguens RP

Severe mitral regurgitation after radiotherapy.

Echocardiography (Mount Kisco, N.Y.) 2014 Feb;31;E37-40 — 2014 Feb — E37-40

Cella L, Liuzzi R, Conson M, Torre G, Caterino M, De Rosa N, Picardi M, Camera L, Solla R, Farella A, Salvatore M, Pacelli R

Dosimetric predictors of asymptomatic heart valvular dysfunction following mediastinal irradiation for Hodgkin's lymphoma.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2011 Nov;101;316-21 — 2011 Nov — 316-21

Ichinose T, Nakazato Y, Miyano H, Kimura T, Yamashita H, Takizawa K, Kawai S, Daida H, Kawasaki S, Amano A

Severe infundibular pulmonary stenosis and coronary artery stenosis with ventricular tachycardia 24 years after mediastinal irradiation.

Internal medicine (Tokyo, Japan) 2005 Sep;44;963-6 — 2005 Sep — 963-6