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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XII.b

Valvular heart disease and/or dysfunction

Review at PMID 24092234

Publications

Parkhomenko RA, Shcherbenko OI, Rybakova MK, Zelinskaya NI, Kharchenko NV, Kunda MA, Zapirov GM

Changes of the Heart Valves in the Long Term After Chemoradiotherapy According to Different Protocols for Hodgkin's Lymphoma in Children and Adolescents.

Journal of adolescent and young adult oncology. 2019;8(4):410-416

Cella L, Oh JH, Deasy JO, Palma G, Liuzzi R, D'avino V, Conson M, Picardi M, Salvatore M, Pacelli R

Predicting radiation-induced valvular heart damage.

Acta oncologica (Stockholm, Sweden). 2015;54(10):1796-804

Desai MY, Karunakaravel K, Wu W, Agarwal S, Smedira NG, Lytle BW, Griffin BP

Pulmonary fibrosis on multidetector computed tomography and mortality in patients with radiation-associated cardiac disease undergoing cardiac surgery.

The Journal of thoracic and cardiovascular surgery. 2014;148(2):475-81.e3

Cozzarín A, Cianciulli TF, Saccheri MC, Lax JA, Simonetti ME, Zappi A, Laguens RP

Severe mitral regurgitation after radiotherapy.

Echocardiography (Mount Kisco, N.Y.). 2014;31(2):E37-40

Cella L, Liuzzi R, Conson M, Torre G, Caterino M, De Rosa N, Picardi M, Camera L, Solla R, Farella A, Salvatore M, Pacelli R

Dosimetric predictors of asymptomatic heart valvular dysfunction following mediastinal irradiation for Hodgkin's lymphoma.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2011;101(2):316-21

Ichinose T, Nakazato Y, Miyano H, Kimura T, Yamashita H, Takizawa K, Kawai S, Daida H, Kawasaki S, Amano A

Severe infundibular pulmonary stenosis and coronary artery stenosis with ventricular tachycardia 24 years after mediastinal irradiation.

Internal medicine (Tokyo, Japan). 2005;44(9):963-6