The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

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Abnormal lung function/pulmonary physiology (PFTs) without necessarily imaging or clinical evidence

Correlate with involved field and radiation dose

Publications

De A, Kamath S, Wong K, Olch AJ, Malvar J, Sposto R, Mascarenhas L, Keens TG, Venkatramani R

Correlation of pulmonary function abnormalities with dose volume histograms in children treated with lung irradiation.

Pediatric pulmonology 2015 Jun;50;596-603 — 2015 Jun — 596-603

Venkatramani R, Kamath S, Wong K, Olch AJ, Malvar J, Sposto R, Goodarzian F, Freyer DR, Keens TG, Mascarenhas L

Pulmonary outcomes in patients with Hodgkin lymphoma treated with involved field radiation.

Pediatric blood & cancer 2014 Jul;61;1277-81 — 2014 Jul — 1277-81

Motosue MS, Zhu L, Srivastava K, Stokes DC, Hudson MM, McPherson V, Srinivasan S, Krasin MJ, Green DM, Spunt SL, Inaba H

Pulmonary function after whole lung irradiation in pediatric patients with solid malignancies.

Cancer 2012 Mar 01;118;1450-6 — 2012 Mar 01 — 1450-6

Myers JN, O'neil KM, Walsh TE, Hoffmeister KJ, Venzon DJ, Johnson BE

The pulmonary status of patients with limited-stage small cell lung cancer 15 years after treatment with chemotherapy and chest irradiation.

Chest 2005 Nov;128;3261-8 — 2005 Nov — 3261-8