The Drug-Induced Respiratory Disease Website and App

Radiation therapy (medium term & late effects)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LI.am

Late left ventricular dysfunction/failure

Publications

Myrehaug S, Pintilie M, Tsang R, Mackenzie R, Crump M, Chen Z, Sun A, Hodgson DC

Cardiac morbidity following modern treatment for Hodgkin lymphoma: supra-additive cardiotoxicity of doxorubicin and radiation therapy.

Leukemia & lymphoma 2008 Aug;49;1486-93 — 2008 Aug — 1486-93

Bölling T, Könemann S, Ernst I, Willich N

Late effects of thoracic irradiation in children.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 2008 Jun;184;289-95 — 2008 Jun — 289-95