The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Aspiration, aspiration pneumonia (w/wo demonstrable pharyngeal dysmotility)
Particularly following radiation therapy for head and neck malignancies.
Publications
A case of diffuse aspiration bronchiolitis due to oesophageal stenosis after radiation therapy.
Respirology case reports 2021 Nov;9;e0855 — 2021 Nov — e0855
Posttreatment CT and MR imaging in head and neck cancer: what the radiologist needs to know.
Radiographics : a review publication of the Radiological Society of North America, Inc 2012 Sep-Oct;32;1261-82; discussion 1282-4 — 2012 Sep-Oct — 1261-82; discussion 1282-4
Logemann JA, Pauloski BR, Rademaker AW, Lazarus CL, Gaziano J, Stachowiak L, Newman L, MacCracken E, Santa D, Mittal B
Swallowing disorders in the first year after radiation and chemoradiation.
Head & neck 2008 Feb;30;148-58 — 2008 Feb — 148-58
Dysphagia in patients with nasopharyngeal cancer after radiation therapy: a videofluoroscopic swallowing study.
Dysphagia 2003;18;135-43 — 2003 — 135-43