Back to drug

The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XI.g

Aspiration, aspiration pneumonia (w/wo demonstrable pharyngeal dysmotility)

Particularly following radiation therapy for head and neck malignancies.

Publications

Horimoto K, Kai Y, Fukuoka A, Tamaki S, Yoshikawa M, Hamada K, Muro S

A case of diffuse aspiration bronchiolitis due to oesophageal stenosis after radiation therapy.

Respirology case reports. 2021;9(11):e0855

Saito N, Nadgir RN, Nakahira M, Takahashi M, Uchino A, Kimura F, Truong MT, Sakai O

Posttreatment CT and MR imaging in head and neck cancer: what the radiologist needs to know.

Radiographics : a review publication of the Radiological Society of North America, Inc. 2012;32(5):1261-82; discussion 1282-4

Logemann JA, Pauloski BR, Rademaker AW, Lazarus CL, Gaziano J, Stachowiak L, Newman L, MacCracken E, Santa D, Mittal B

Swallowing disorders in the first year after radiation and chemoradiation.

Head & neck. 2008;30(2):148-58

Chang YC, Chen SY, Lui LT, Wang TG, Wang TC, Hsiao TY, Li YW, Lien IN

Dysphagia in patients with nasopharyngeal cancer after radiation therapy: a videofluoroscopic swallowing study.

Dysphagia. 2003;18(2):135-43