The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Heart block (bundle branch- or AV-)
Review at 24092234
Publications
Radiation therapy-induced cardiac injury.
American heart journal. 1995;129(6):1193-6
Complete heart block and severe tricuspid regurgitation after radiotherapy. Case report and review of the literature.
Chest. 1995;108(6):1748-51
Slama MS, Le Guludec D, Sebag C, Leenhardt AR, Davy JM, Pellerin DE, Drieu LH, Victor J, Brechenmacher C, Motté G
Complete atrioventricular block following mediastinal irradiation: a report of six cases.
Pacing and clinical electrophysiology : PACE. 1991;14(7):1112-8