The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (interstitial lung disease/ILD)

Publications

Hassaballa HA, Cohen ES, Khan AJ, Ali A, Bonomi P, Rubin DB

Positron emission tomography demonstrates radiation-induced changes to nonirradiated lungs in lung cancer patients treated with radiation and chemotherapy.

Chest 2005 Sep;128;1448-52 — 2005 Sep — 1448-52

Martín C, Romero S, Sánchez-Payá J, Massuti B, Arriero JM, Hernández L

Bilateral lymphocytic alveolitis: a common reaction after unilateral thoracic irradiation.

The European respiratory journal 1999 Apr;13;727-32 — 1999 Apr — 727-32