The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Path: Pneumocyte atypia (reactive epithelial cells) (a.k.a. the "Napoleon Hat" sign)
Publications
"Napoleon Hat" Sign: A Distinctive Cytologic Clue to Reactive Pneumocytes.
Archives of pathology & laboratory medicine 2020 Jan 23;; — 2020 Jan 23
Bilateral radiation pneumonitis after unilateral lung and mediastinal irradiation.
Radiologia clinica et biologica 1974;43;465-71 — 1974 — 465-71
Low-dose radiation pneumonitis.
Cancer 1975 May;35;1322-4 — 1975 May — 1322-4