The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Coronary artery disease (subacute, chronic)
Review at 24092234
Publications
How to prevent and manage radiation-induced coronary artery disease.
Heart (British Cardiac Society) 2018 10;104;1647-1653 — 2018 10 — 1647-1653
Pulmonary fibrosis on multidetector computed tomography and mortality in patients with radiation-associated cardiac disease undergoing cardiac surgery.
The Journal of thoracic and cardiovascular surgery 2014 Aug;148;475-81.e3 — 2014 Aug — 475-81.e3
Baker JE, Fish BL, Su J, Haworth ST, Strande JL, Komorowski RA, Migrino RQ, Doppalapudi A, Harmann L, Allen Li X, Hopewell JW, Moulder JE
10 Gy total body irradiation increases risk of coronary sclerosis, degeneration of heart structure and function in a rat model.
International journal of radiation biology 2009 Dec;85;1089-100 — 2009 Dec — 1089-100
Ichinose T, Nakazato Y, Miyano H, Kimura T, Yamashita H, Takizawa K, Kawai S, Daida H, Kawasaki S, Amano A
Severe infundibular pulmonary stenosis and coronary artery stenosis with ventricular tachycardia 24 years after mediastinal irradiation.
Internal medicine (Tokyo, Japan) 2005 Sep;44;963-6 — 2005 Sep — 963-6
Symptomatic coronary artery disease after mantle irradiation for Hodgkin's disease.
International journal of radiation oncology, biology, physics 1996 Nov 01;36;881-9 — 1996 Nov 01 — 881-9