The Drug-Induced Respiratory Disease Website and App

Radiation therapy (medium term & late effects)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

V.a

Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

Publications

Yamamoto N, Noda Y, Miyashita Y

A case of refractory bilateral pleural effusion due to post-irradiation constrictive pericarditis.

Respirology (Carlton, Vic.). 2002;7(4):365-8

Morrone N, Gama e Silva Volpe VL, Dourado AM, Mitre F, Coletta EN

Bilateral pleural effusion due to mediastinal fibrosis induced by radiotherapy.

Chest. 1993;104(4):1276-8

Rodríguez-García JL, Fraile G, Moreno MA, Sánchez-Corral JA, Peñalver R

Recurrent massive pleural effusion as a late complication of radiotherapy in Hodgkin's disease.

Chest. 1991;100(4):1165-6

Ruckdeschel JC, Chang P, Martin RG, Byhardt RW, O'Connell MJ, Sutherland JC, Wiernik PH

Radiation-related pericardial effusions in patients with Hodgkin's disease.

Medicine. 1975;54(3):245-59