The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VIII.au

Large airway necrosis

Publications

Duijm M, Schillemans W, Aerts JG, Heijmen B, Nuyttens JJ

Dose and Volume of the Irradiated Main Bronchi and Related Side Effects in the Treatment of Central Lung Tumors With Stereotactic Radiotherapy.

Seminars in radiation oncology. 2016;26(2):140-8

Alraiyes AH, Alraies MC, Abbas A

Radiation-associated airway necrosis.

Ochsner journal. 2013;13(2):273-5

Corradetti MN, Haas AR, Rengan R

Central-airway necrosis after stereotactic body-radiation therapy.

The New England journal of medicine. 2012;366(24):2327-9

Mehta AC, Dweik RA

Necrosis of the bronchus. Role of radiation.

Chest. 1995;108(5):1462-6