The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.e

Organizing pneumonia pattern (an area or areas of consolidation on imaging)

Some papers refer to organizing pneumonia on the basis of imaging (Ex Oie et al. PMID 23497657). However, only pathology can confirm an organizing pneumonia is present

Publications

Oie Y, Saito Y, Kato M, Ito F, Hattori H, Toyama H, Kobayashi H, Katada K

Relationship between radiation pneumonitis and organizing pneumonia after radiotherapy for breast cancer.

Radiation oncology (London, England) 2013 Mar 08;8;56 — 2013 Mar 08 — 56

Ogo E, Komaki R, Abe T, Uchida M, Fujimoto K, Suzuki G, Tsuji C, Suefuji H, Etou H, Hattori C, Watanabe Y, Hayabuchi N

The clinical characteristics and non-steroidal treatment for radiation-induced bronchiolitis obliterans organizing pneumonia syndrome after breast-conserving therapy.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2010 Oct;97;95-100 — 2010 Oct — 95-100

Diederich S, Eidt S, Lüthen R

[Multiple bilateral pulmonary nodes following breast cancer].

Deutsche medizinische Wochenschrift (1946) 2009 May;134;981-4 — 2009 May — 981-4

Katayama N, Sato S, Katsui K, Takemoto M, Tsuda T, Yoshida A, Morito T, Nakagawa T, Mizuta A, Waki T, Niiya H, Kanazawa S

Analysis of factors associated with radiation-induced bronchiolitis obliterans organizing pneumonia syndrome after breast-conserving therapy.

International journal of radiation oncology, biology, physics 2009 Mar 15;73;1049-54 — 2009 Mar 15 — 1049-54

Ogo E, Komaki R, Fujimoto K, Uchida M, Abe T, Nakamura K, Mitsumori M, Sekiguchi K, Kaneyasu Y, Hayabuchi N

A survey of radiation-induced bronchiolitis obliterans organizing pneumonia syndrome after breast-conserving therapy in Japan.

International journal of radiation oncology, biology, physics 2008 May 01;71;123-31 — 2008 May 01 — 123-31

Cornelissen R, Senan S, Antonisse IE, Liem H, Tan YK, Rudolphus A, Aerts JG

Bronchiolitis obliterans organizing pneumonia (BOOP) after thoracic radiotherapy for breast carcinoma.

Radiation oncology (London, England) 2007 Jan 03;2;2 — 2007 Jan 03 — 2

Bayle JY, Nesme P, Béjui-Thivolet F, Loire R, Guérin JC, Cordier JF

Migratory organizing pneumonitis "primed" by radiation therapy.

The European respiratory journal 1995 Feb;8;322-6 — 1995 Feb — 322-6

Crestani B, Kambouchner M, Soler P, Crequit J, Brauner M, Battesti JP, Valeyre D

Migratory bronchiolitis obliterans organizing pneumonia after unilateral radiation therapy for breast carcinoma.

The European respiratory journal 1995 Feb;8;318-21 — 1995 Feb — 318-21