The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.v

Abnormal lung function/pulmonary physiology (PFTs) without necessarily imaging or clinical evidence

Publications

Jaén J, Vázquez G, Alonso E, De Las Peñas MD, Díaz L, De Las Heras M, Pérez-Regadera JF

Long-term changes in pulmonary function after incidental lung irradiation for breast cancer: a prospective study with 7-year follow-up.

International journal of radiation oncology, biology, physics. 2012;84(5):e565-70

Erven K, Weltens C, Nackaerts K, Fieuws S, Decramer M, Lievens Y

Changes in pulmonary function up to 10 years after locoregional breast irradiation.

International journal of radiation oncology, biology, physics. 2012;82(2):701-7