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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.m

Bronchial stenosis/stricture

Publications

van Hoorn JE, Dahele M, Daniels JMA

Bronchoscopic Manifestations of Airway Toxicity After Radiotherapy.

Clinical lung cancer. 2018;19(6):e875-e878

Eom JS, Kim B, Kim H, Jeon K, Um SW, Koh WJ, Suh GY, Chung MP, Kwon OJ

Fibrotic airway stenosis following radiotherapy in patients with adenoid cystic carcinoma.

Respirology (Carlton, Vic.). 2014;19(6):914-20

Miller KL, Shafman TD, Anscher MS, Zhou SM, Clough RW, Garst JL, Crawford J, Rosenman J, Socinski MA, Blackstock W, Sibley GS, Marks LB

Bronchial stenosis: an underreported complication of high-dose external beam radiotherapy for lung cancer?

International journal of radiation oncology, biology, physics. 2005;61(1):64-9

Awan AN, Ashraf R, Meyerson MB, Dunn TL

Radiation-induced bronchial stenosis: a new cause of platypnea-orthodeoxia.

Southern medical journal. 1999;92(7):720-4

Dechambre St, Dorzee J, Fastrez J, Hanzen C, Van Houtte P, d'Odémont JP

Bronchial stenosis and sclerosing mediastinitis: an uncommon complication of external thoracic radiotherapy.

The European respiratory journal. 1998;11(5):1188-90