The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Organizing pneumonia pattern (an area or areas of consolidation on imaging)
Although apparently effective, corticosteroid therapy is not indicated in every patient and may promote relapse or relapses upon tapering (PMID 30705815)
Publications
Spontaneous resolution of thoracic radiation therapy-induced organizing pneumonia: A case series.
Respiratory medicine case reports. 2019;26:180-184
Systematic review of postradiotherapy bronchiolitis obliterans organizing pneumonia in women with breast cancer.
The oncologist. 2014;19(12):1216-26
Bronchiolitis obliterans organizing pneumonia syndrome primed by radiation therapy to the breast. The Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires (GERM"O"P).
American journal of respiratory and critical care medicine. 1998;158(6):1929-35
Migratory bronchiolitis obliterans organizing pneumonia after unilateral radiation therapy for breast carcinoma.
The European respiratory journal. 1995;8(2):318-21