The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Valvular heart disease and/or dysfunction
See more specifically under 'Radiation therapy (late effects')
Publications
Báez-Ferrer N, Izquierdo-Gómez MM, Beyello-Belkasem C, Jorge-Pérez P, García-González MJ, Ferrer-Hita JJ, De la Rosa-Hernández A, García-Niebla J, Lacalzada-Almeida J
Long-Term Radiotherapy-Induced Cardiac Complications: A Case Report.
The American journal of case reports 2019 Aug 11;20;1182-1188 — 2019 Aug 11 — 1182-1188
Severe mitral regurgitation after radiotherapy.
Echocardiography (Mount Kisco, N.Y.) 2014 Feb;31;E37-40 — 2014 Feb — E37-40
Cella L, Liuzzi R, Conson M, Torre G, Caterino M, De Rosa N, Picardi M, Camera L, Solla R, Farella A, Salvatore M, Pacelli R
Dosimetric predictors of asymptomatic heart valvular dysfunction following mediastinal irradiation for Hodgkin's lymphoma.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2011 Nov;101;316-21 — 2011 Nov — 316-21