Radiation therapy (medium term & late effects)
Review at PMID 27261350. Radiation therapy and the heart: PMID 7754953
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The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
I - Interstitial/parenchymal lung disease
I.c
Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
I.e
Organizing pneumonia pattern (an area or areas of consolidation on imaging)
I.g
Pulmonary fibrosis
I.i
Subclinical pulmonary infiltrates/ILD
I.p
Focal/localized area of pneumonitis/fibrosis
I.w
Abnormal lung function/pulmonary physiology (PFTs) without necessarily imaging or clinical evidence
I.y
Pleuroparenchymal fibroelastosis (PPFE)
XLI - Pulmonary edema - Acute lung injury - ARDS
XLII - Pulmonary/alveolar./airway hemorrhage/bleeding
XLIII - Airway involvement
XLIV - Central-large-upper airway (incl. pharyngeal-nasal) involvement
XLIV.c
Upper airway obstruction other than angioedema or hematoma
XLIV.d
Laryngeal disorder-Laryngeal nerve palsy (dysphonia, hoarseness)
XLIV.g
Vocal cord paresis/paralysis
XLIV.s
Tracheal/large airway necrosis, chondronecrosis, perforation
XLIV.aa
Pseudomembranous tracheitis/tracheobronchitis
XLIV.ab
Airway (e.g. tracheoesophageal) fistula
XLIV.ac
Large airway necrosis
XLV - Pleural and/or pericardial involvement
XLV.a
Pleural effusion (uni- or bilateral) (can accompany DI-LDs)
XLV.b
Eosinophilic pleural effusion
XLV.c
Pleural thickening - Fibrothorax
XLV.f
Pneumothorax
XLV.h
Chylothorax
XLV.l
Malignant pleural mesothelioma
XLV.m
Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)
XLV.u
The apical cap
XLVI - Pulmonary vasculopathy
XLVII - Mediastinal involvement
XLVIII - Neuromuscular / CNS involvement - Disordered breathing (during sleep)
L - Miscellaneous
LI - Cardiovascular involvement / toxicity
LI.a
Left or biventricular dysfunction/failure
LI.b
Valvular heart disease and/or dysfunction
LI.g
Cardiomyopathy (acute, subacute, chronic)
LI.h
Coronary artery disease (acute) - Myocardial ischemia/infarction
LI.l
Constrictive pericarditis - Pericardial thickening
LI.p
Coronary artery disease (subacute, chronic)
LI.t
Heart block (bundle branch- or AV-)
LI.af
Effusive-constrictive pericarditis
LI.am
Late left ventricular dysfunction/failure
LI.ap
Pericardial calcification
LI.bf
Coarctation of the aorta (acquired)
LI.bx
Aortoesophageal fistula
LII - Esophageal involvement
LV - Imaging
LV.ac
Imaging: Cavitating/cavitary lung nodule, mass or nodules (see also Iq, XIs, XIIi, XVIaa and XVIIp)
LV.bm
Imaging: Hyperlucent lung
LV.bn
Imaging: Atelectasis (a combination of increased density and volume loss. Typically lobar)
LV.bp
Imaging: An area or areas of avid tracer uptake in the lung/chest on 18F-PET scan