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XLIV.l

XLIV - Central-large-upper airway (incl. pharyngeal-nasal) involvement

Midline destructive lesions

Last update 21/09/2014

Include destruction of the turbinates, nasal septum and ulceration and perforation of the hard palate. May mimic the clinical ENT manifestations and some of the laboratory features of granulomatous polyangiitis (formerly known as Wegener). Up to half the patients may demonstrate positive ANCA staining. Osteomyelitis and fungal colonization or infection may develop (PMID: 11605572, 25229300). See also under Xm, Xs( ANCA-positive vasculitis) and Xx

Causative drugs

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases