The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.d

Exacerbation or deterioration of preexisting COPD

Publications

Rong Y, Bentley JP, McGwin G, Yang Y, Banahan BF, Noble SL, Kirby T, Ramachandran S

Association between Transient Opioid Use and Short-term Respiratory Exacerbation among Adults with Chronic Obstructive Pulmonary Disease (COPD): A Case-crossover Study.

American journal of epidemiology 2019 Jul 30;; — 2019 Jul 30