The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLVIII.d

Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

Publications

Schneir AB, Vadeboncoeur TF, Offerman SR, Barry JD, Ly BT, Williams SR, Clark RF

Massive OxyContin ingestion refractory to naloxone therapy.

Annals of emergency medicine 2002 Oct;40;425-8 — 2002 Oct — 425-8

Leino K, Mildh L, Lertola K, Seppälä T, Kirvelä O

Time course of changes in breathing pattern in morphine- and oxycodone-induced respiratory depression.

Anaesthesia 1999 Sep;54;835-40 — 1999 Sep — 835-40