The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.s

Vasculitis, pulmonary (w/wo AH), extrapulmonary, systemic: ANCA-positive

Pathophysiology at PMID 27354687

Publications

Bucur P, Weber M, Agrawal R, Madera-Acosta AI, Elam RE

Pulmonary-Renal Syndrome from Levamisole-Adulterated Cocaine-Induced Antineutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis: A Systematic Review.

Pharmaceuticals (Basel, Switzerland). 2023;16(6)

Ruffer N, Krusche M, Holl-Ulrich K, Kötter I, Lötscher F

[Cocaine-induced vasculitis and mimics of vasculitis].

Zeitschrift fur Rheumatologie. 2023;82(7):606-614

Agdamag AC, Gevorgyan O, Lawrenz Co M, Hassan S

Multiple cutaneous and mucosal lesions in a patient with cocaine-levamisole-induced vasculopathy syndrome.

Proceedings (Baylor University. Medical Center). 2019;32(1):93-95

Jin Q, Kant S, Alhariri J, Geetha D

Levamisole adulterated cocaine associated ANCA vasculitis: review of literature and update on pathogenesis.

Journal of community hospital internal medicine perspectives. 2018;8(6):339-344

Boyd AS, Ortleb M

Levamisole-induced vasculopathy with gastric involvement in a cocaine user.

Cutis. 2018;102(3):169;170;175;176

Kumar D, Batal I, Jim B, Mendez B, Anis K

Unusual case of levamisole-induced dual-positive ANCA vasculitis and crescentic glomerulonephritis.

BMJ case reports. 2018;2018

Muñoz-Vahos CH, Herrera-Uribe S, Arbeláez-Cortés Á, Jaramillo-Arroyave D, González-Naranjo LA, Vásquez-Duque G, Restrepo-Escobar M, Correa-Londoño LA, Arias-Restrepo LF, Vanegas-García AL

Clinical Profile of Levamisole-Adulterated Cocaine-Induced Vasculitis/Vasculopathy: A 30-Case Series.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. 2019;25(3):e16-e26

Subesinghe S, van Leuven S, Yalakki L, Sangle S, D'Cruz D

Cocaine and ANCA associated vasculitis-like syndromes - A case series.

Autoimmunity reviews. 2018;17(1):73-77

Fan T, Macaraeg J, Haddad TM, Bacon H, Le D, Mirza M, Valenta C, Wichman T

A Case Report on Suspected Levamisole-Induced Pseudovasculitis.

WMJ : official publication of the State Medical Society of Wisconsin. 2017;116(1):37-9

Marquez J, Aguirre L, Muñoz C, Echeverri A, Restrepo M, Pinto LF

Cocaine-Levamisole-Induced Vasculitis/Vasculopathy Syndrome.

Current rheumatology reports. 2017;19(6):36

Collister D, Sathianathan C, Ryz K, Karpinski M, Bernstein K, Gibson IW

ANCA Associated Vasculitis Secondary to Levamisole-Adultered Cocaine with Associated Membranous Nephropathy: A Case Series.

American journal of nephrology. 2017;45(3):209-216

Garg L, Gupta S, Swami A, Zhang P

Levamisole/Cocaine Induced Systemic Vasculitis and Immune Complex Glomerulonephritis.

Case reports in nephrology. 2015;2015:372413

Alqalyoobi S, Vaidya O, Abu Ghanimah AM, Elkhanany A, Gohar A

Cocaine induced pleural and pericardial effusion syndrome.

Case reports in pulmonology. 2015;2015:321539

Sarkar D, Kammona HA, Lamsen LN, McAbee BA, Clark CT, Lee SS, Kelley SE

Photoletter to the editor: Diffuse cocaine-related purpura.

Journal of dermatological case reports. 2013;7(4):132-3

Pendergraft WF 3rd, Niles JL

Trojan horses: drug culprits associated with antineutrophil cytoplasmic autoantibody (ANCA) vasculitis.

Current opinion in rheumatology. 2014;26(1):42-9