Philippe Camus, M.D.

Dijon, France

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The Drug-Induced Respiratory Disease Website and App

L.e

L - Miscellaneous

Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea

Last update 17/06/2026

See also under IXg and h. Salbutamol/albuterol and methanol are notable for inducing lactic acidosis and anion gap. Reactional dyspnea and/or hyperpnea can be present. To quote Klig et al. (2014) (PMID 25140963) 'The differential diagnosis of an elevated anion-gap metabolic acidosis is detailed by the acronym 'CAT MUDPILES''. Review of drug-induced AB disorders at PMID 25370778

Causative drugs

35

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Acetazolamide
XLI.a
XLVIII.a
XLIX.f
L.e
LI.o
LXII.a
LXII.b
Adrenaline (epinephrine)
XLI.a
XLI.b
XLI.k
L.b
L.e
LI.f
LI.g
LI.h
LI.k
LI.n
LI.v
LI.y
LI.ah
LI.as
Almitrine
L.e
Aspirin (Salicylate-ASA) - Aspirin containing drugs
I.b
I.c
I.m
XLI.a
XLI.e
XLII.a
XLII.c
XLII.m
XLIII.a
XLIII.b
XLIV.a
XLIV.y
XLV.e
XLVII.b
XLIX.a
XLIX.f
XLIX.j
XLIX.o
XLIX.s
XLIX.w
L.b
L.e
L.ap
L.au
LI.o
LI.t
LI.ah
LVIII.a
LVIII.o
LVIII.t
Benzonatate
XLIII.a
L.e
LI.n
LI.u
Beta-2 agonists, B2 mimetics (parenteral)
XLI.a
XLI.b
XLI.j
XLVIII.i
L.e
LI.f
LI.g
Cade oil
XLI.p
L.e
Carbonic anhydrase inhibitors
L.e
Clenbuterol
L.b
L.e
LI.o
Cyanide
L.e
L.bd
Diethylene glycol
XLVIII.d
L.e
Dinitrophenol (2, 4-dinitrophenol or DNP)
XLI.a
XLI.b
XLI.p
XLI.r
XLIV.c
XLIV.z
XLVIII.c
XLVIII.k
XLIX.w
XLIX.av
L.e
L.o
LI.n
LI.u
LIII.a
LXIII.a
Ethylene glycol
L.e
LXVII.a
Excipients-Vehicle-Preservatives (of drugs)
I.c
I.d
I.e
I.g
I.n
I.u
XLI.a
XLIII.a
XLIII.b
XLIII.z
XLVI.b
XLVI.e
XLVI.g
XLIX.f
XLIX.h
XLIX.i
XLIX.w
L.e
LI.o
LV.q
LV.v
LVIII.ab
LVIII.be
Hand sanitizer (fluid)
XLVIII.i
L.e
L.o
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