The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XI.d

Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea

Publications

Beaulieu J, Roberts DM, Gosselin S, Hoffman RS, Lavergne V, Hovda KE, Megarbane B, Lung D, Thanacoody R, Ghannoum M

Treating ethylene glycol poisoning with alcohol dehydrogenase inhibition, but without extracorporeal treatments: a systematic review.

Clinical toxicology (Philadelphia, Pa.). 2022;60(7):784-797

Sagar AS, Jimenez CA, Mckelvy BJ

Lactate gap as a tool in identifying ethylene glycol poisoning.

BMJ case reports. 2018;2018

Narita I, Shimada M, Nakamura N, Murakami R, Fujita T, Fukuda W, Tomita H

Successful Resuscitation of a Patient with Life-Threatening Metabolic Acidosis by Hemodialysis: A Case of Ethylene Glycol Intoxication.

Case reports in nephrology. 2017;2017:9529028

Cooper CM, Baron JM

Case records of the Massachusetts General Hospital. Case 4-2015. A 49-year-old man with obtundation followed by agitation and acidosis.

The New England journal of medicine. 2015;372(5):465-73

Narins RG, Rudnick MR, Bastl CP

Case 38-1979: Ethylene glycol poisoning.

The New England journal of medicine. 1980;302(8):466