The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea
Publications
Beaulieu J, Roberts DM, Gosselin S, Hoffman RS, Lavergne V, Hovda KE, Megarbane B, Lung D, Thanacoody R, Ghannoum M
Treating ethylene glycol poisoning with alcohol dehydrogenase inhibition, but without extracorporeal treatments: a systematic review.
Clinical toxicology (Philadelphia, Pa.) 2022 Mar 21;;1-14 — 2022 Mar 21 — 1-14
Lactate gap as a tool in identifying ethylene glycol poisoning.
BMJ case reports 2018 Mar 09;2018; — 2018 Mar 09
Successful Resuscitation of a Patient with Life-Threatening Metabolic Acidosis by Hemodialysis: A Case of Ethylene Glycol Intoxication.
Case reports in nephrology 2017;2017;9529028 — 2017 — 9529028
Case records of the Massachusetts General Hospital. Case 4-2015. A 49-year-old man with obtundation followed by agitation and acidosis.
The New England journal of medicine 2015 Jan 29;372;465-73 — 2015 Jan 29 — 465-73
Case 38-1979: Ethylene glycol poisoning.
The New England journal of medicine 1980 Feb 21;302;466 — 1980 Feb 21 — 466