The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Severe or catastrophic bronchospasm or asthma attack (can be fatal)
Tests to document AERD at PMID 17521312. Induction of tolerance/desensitization at PMID 23861151, 24369807
Publications
Samter's triad in childhood: a warning for those prescribing NSAIDs.
Paediatric anaesthesia 2013 Aug;23;757-9 — 2013 Aug — 757-9
Aspirin-intolerance as a precipitating factor of life-threatening attacks of asthma requiring mechanical ventilation.
The European respiratory journal 1989 Feb;2;127-9 — 1989 Feb — 127-9