The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.a

Pulmonary edema, noncardiogenic (NCPE)

Publications

Lee SJ, Son S, Kim J

Noncardiogenic pulmonary edema triggered by acetazolamide, a rare complication of acetazolamide challenge test.

Journal of cerebrovascular and endovascular neurosurgery 2026 Apr 30;; — 2026 Apr 30

García M, Albizua Madariaga I, Sainz-Gil M, Lertxundi U

Acetazolamide-induced pulmonary oedema: A disproportionality analysis from the EudraVigilance database.

British journal of clinical pharmacology 2024 Jul;90;1751-1755 — 2024 Jul — 1751-1755

Schwartz AH, Sieminski S

Acetazolamide induced noncardiogenic pulmonary edema, an underreported serious adverse event.

American journal of ophthalmology case reports 2023 Jun;30;101827 — 2023 Jun — 101827

Ono Y, Morifusa M, Ikeda S, Kunishige C, Tohma Y

A case of non-cardiogenic pulmonary edema provoked by intravenous acetazolamide.

Acute medicine & surgery 2017 Jul;4;349-352 — 2017 Jul — 349-352

Guven Yilmaz S, Palamar M, Gurgun C

Acute pulmonary oedema due to single dose acetazolamide taken after cataract surgery.

BMJ case reports 2016 May 11;2016; — 2016 May 11

Zimmermann S, Achenbach S, Wolf M, Janka R, Marwan M, Mahler V

Recurrent shock and pulmonary edema due to acetazolamide medication after cataract surgery.

Heart & lung : the journal of critical care 2014 Mar-Apr;43;124-6 — 2014 Mar-Apr — 124-6

Vogiatzis I, Koulouris E, Sidiropoulos A, Giannakoulas C

Acute pulmonary edema after a single oral dose of acetazolamide.

Hippokratia 2013 Apr;17;177-9 — 2013 Apr — 177-9

Gallerani M, Manzoli N, Fellin R, Simonato M, Orzincolo C

Anaphylactic shock and acute pulmonary edema after a single oral dose of acetazolamide.

The American journal of emergency medicine 2002 Jul;20;371-2 — 2002 Jul — 371-2