The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Coronary artery disease (acute) - Myocardial ischemia/infarction
Publications
ACE-I Angioedema: Accurate Clinical Diagnosis May Prevent Epinephrine-Induced Harm.
The western journal of emergency medicine. 2016;17(3):283-9
Adrenaline in anaphylaxis treatment. Balancing benefits and harms.
Expert opinion on drug safety. 2016;15(6):741-6
Myocardial ischaemia following cocaine and adrenaline exposure in a child during an ophthalmological procedure.
Irish medical journal. 2015;108(3):89-90
Epinephrine-induced myocardial infarction in severe anaphylaxis: is nonselective β-blockade a contributory factor?
The American journal of emergency medicine. 2013;31(4):759.e1-2
Wandering coronary stenoses: adrenaline-induced coronary artery spasm in a patient resuscitated from cardiac arrest.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 2010;75(7):1056-9
Lessons for management of anaphylaxis from a study of fatal reactions.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2000;30(8):1144-50