The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.f

Anaphylaxis-Anaphylactoid reaction (can be fatal)

Publications

Vogiatzis I, Koulouris E, Sidiropoulos A, Giannakoulas C

Acute pulmonary edema after a single oral dose of acetazolamide.

Hippokratia 2013 Apr;17;177-9 — 2013 Apr — 177-9

Gallerani M, Manzoli N, Fellin R, Simonato M, Orzincolo C

Anaphylactic shock and acute pulmonary edema after a single oral dose of acetazolamide.

The American journal of emergency medicine 2002 Jul;20;371-2 — 2002 Jul — 371-2

Tzanakis N, Metzidaki G, Thermos K, Spyraki CH, Bouros D

Anaphylactic shock after a single oral intake of acetazolamide.

The British journal of ophthalmology 1998 May;82;588 — 1998 May — 588