The Drug-Induced Respiratory Disease Website and App

Aspirin (Salicylate-ASA) - Aspirin containing drugs

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.a

Pulmonary edema, noncardiogenic (NCPE)

Systemic inflammatory response, MODS and pseudo-sepsis can be present. Measurement of salicylate levels in plasma instrumental to diagnose aspirin-related NCPE

Publications

Otani Y, Kanno K, Toh Yoon EW, Tazuma S

Acute respiratory distress syndrome caused by salicylate intoxication.

Clinical case reports 2018 Sep;6;1905-1906 — 2018 Sep — 1905-1906

Yuklyaeva N, Chaudhary A, Gorantla R, Bischof E

Salicylate-induced pulmonary edema--a near-miss diagnosis.

The American journal of emergency medicine 2014 May;32;490.e5-6 — 2014 May — 490.e5-6

Schou M, Svennum V

[Acute salicylate poisoning may cause non-cardiogenic pulmonary edema].

Lakartidningen 2012 Mar 28-Apr 3;109;700-1 — 2012 Mar 28-Apr 3 — 700-1

Glisson JK, Vesa TS, Bowling MR

Current management of salicylate-induced pulmonary edema.

Southern medical journal 2011 Mar;104;225-32 — 2011 Mar — 225-32

Minns AB, Cantrell FL, Clark RF

Death due to acute salicylate intoxication despite dialysis.

The Journal of emergency medicine 2011 May;40;515-7 — 2011 May — 515-7

Gonzolez ER, Cole T, Grimes MM, Fink RA, Fowler AA

Recurrent ARDS in a 39-year-old woman with migraine headaches.

Chest 1998 Sep;114;919-22 — 1998 Sep — 919-22

Heffner JE, Sahn SA

Salicylate-induced pulmonary edema. Clinical features and prognosis.

Annals of internal medicine 1981 Oct;95;405-9 — 1981 Oct — 405-9

Walters JS, Woodring JH, Stelling CB, Rosenbaum HD

Salicylate-induced pulmonary edema.

Radiology 1983 Feb;146;289-93 — 1983 Feb — 289-93

Fisher CJ, Albertson TE, Foulke GE

Salicylate-induced pulmonary edema: clinical characteristics in children.

The American journal of emergency medicine 1985 Jan;3;33-7 — 1985 Jan — 33-7

Anderson RJ, Potts DE, Gabow PA, Rumack BH, Schrier RW

Unrecognized adult salicylate intoxication.

Annals of internal medicine 1976 Dec;85;745-8 — 1976 Dec — 745-8

Broderick TW, Reinke RT, Goldman E

Salicylate-induced pulmonary edema.

AJR. American journal of roentgenology 1976 Nov;127;865-6 — 1976 Nov — 865-6