The Drug-Induced Respiratory Disease Website and App

Dinitrophenol (2, 4-dinitrophenol or DNP)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LIII.a

Methemoglobinemia

Publications

Grundlingh J, Dargan PI, El-Zanfaly M, Wood DM

2,4-dinitrophenol (DNP): a weight loss agent with significant acute toxicity and risk of death.

Journal of medical toxicology : official journal of the American College of Medical Toxicology 2011 Sep;7;205-12 — 2011 Sep — 205-12

Bartlett J, Brunner M, Gough K

Deliberate poisoning with dinitrophenol (DNP): an unlicensed weight loss pill.

Emergency medicine journal : EMJ 2010 Feb;27;159-60 — 2010 Feb — 159-60