Aspirin-exacerbated respiratory disease (AERD; PMID 24961377) is a naturally-occurring state where aspirin and NSAIDs can produce acute exacerbations and asthma attacks. Tests to document AERD at PMID 17521312. For induction of AS tolerance see PMID 12532116, 23861151, 24369807, 24468245.
Chronic or excessive intake of aspirin can produce pulmonary edema and ARDS (PMID 9743184, 21297545 , 27531848)
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
DRES syndrome - DRESS-like reaction
Anaphylaxis-Anaphylactoid reaction (can be fatal)
Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)
Vascultis (pulmonary, extrathoracic or systemic)-ANCA status unknown or negative)
Systemic inflammatory response
Multiple organ dysfunction/failure (MODS/MOF)
