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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.a

Bronchospasm - Wheezing - Asthma

Tests to document AERD at PMID 17521312. Induction of tolerance/desensitization at PMID 12532116, 23861151, 24369807

Publications

Morales DR, Guthrie B, Lipworth BJ, Jackson C, Donnan PT, Santiago VH

NSAID-exacerbated respiratory disease: a meta-analysis evaluating prevalence, mean provocative dose of aspirin and increased asthma morbidity.

Allergy. 2015;70(7):828-35

Rajan JP, Wineinger NE, Stevenson DD, White AA

Prevalence of aspirin-exacerbated respiratory disease among asthmatic patients: A meta-analysis of the literature.

The Journal of allergy and clinical immunology. 2015;135(3):676-81.e1

Velazquez JR, Teran LM

Aspirin-intolerant asthma: a comprehensive review of biomarkers and pathophysiology.

Clinical reviews in allergy & immunology. 2013;45(1):75-86

Jenneck C, Juergens U, Buecheler M, Novak N

Pathogenesis, diagnosis, and treatment of aspirin intolerance.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2007;99(1):13-21

Gollapudi RR, Teirstein PS, Stevenson DD, Simon RA

Aspirin sensitivity: implications for patients with coronary artery disease.

JAMA. 2004;292(24):3017-23

Jenkins C, Costello J, Hodge L

Systematic review of prevalence of aspirin induced asthma and its implications for clinical practice.

BMJ (Clinical research ed.). 2004;328(7437):434

Babu KS, Salvi SS

Aspirin and asthma.

Chest. 2000;118(5):1470-6

Hoigné RV, Braunschweig S, Zehnder D, Kuenzi UP, Hess T, Leuenberger P

Drug-induced attack of bronchial asthma in inpatients: a 20-year survey of the Comprehensive Hospital Drug Monitoring Programme on adverse drug reactions, Berne/St. Gallen.

European journal of clinical pharmacology. 1997;53(1):81-2

Chan TY

Angioedema and acute asthma attack due to the unexpected occurrence of aspirin in an over-the-counter cold preparation.

The British journal of clinical practice. 1996;50(7):412-3

Fischer TJ, Guilfoile TD, Kesarwala HH, Winant JG Jr, Kearns GL, Gartside PS, Moomaw CJ

Adverse pulmonary responses to aspirin and acetaminophen in chronic childhood asthma.

Pediatrics. 1983;71(3):313-8

Slepian IK, Mathews KP, McLean JA

Aspirin-sensitive asthma.

Chest. 1985;87(3):386-91

Szczeklik A

Aspirin-induced asthma: new insights into pathogenesis and clinical presentation of drug intolerance.

International archives of allergy and applied immunology. 1989;90 Suppl 1:70-5

Abrishami MA, Thomas J

Aspirin intolerance--a review.

Annals of allergy. 1977;39(1):28-37