The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Bronchospasm - Wheezing - Asthma
Tests to document AERD at PMID 17521312. Induction of tolerance/desensitization at PMID 12532116, 23861151, 24369807
Publications
NSAID-exacerbated respiratory disease: a meta-analysis evaluating prevalence, mean provocative dose of aspirin and increased asthma morbidity.
Allergy 2015 Jul;70;828-35 — 2015 Jul — 828-35
Prevalence of aspirin-exacerbated respiratory disease among asthmatic patients: A meta-analysis of the literature.
The Journal of allergy and clinical immunology 2015 Mar;135;676-81.e1 — 2015 Mar — 676-81.e1
Aspirin-intolerant asthma: a comprehensive review of biomarkers and pathophysiology.
Clinical reviews in allergy & immunology 2013 Aug;45;75-86 — 2013 Aug — 75-86
Pathogenesis, diagnosis, and treatment of aspirin intolerance.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2007 Jul;99;13-21 — 2007 Jul — 13-21
Aspirin sensitivity: implications for patients with coronary artery disease.
JAMA 2004 Dec 22;292;3017-23 — 2004 Dec 22 — 3017-23
Systematic review of prevalence of aspirin induced asthma and its implications for clinical practice.
BMJ (Clinical research ed.) 2004 Feb 21;328;434 — 2004 Feb 21 — 434
Aspirin and asthma.
Chest 2000 Nov;118;1470-6 — 2000 Nov — 1470-6
Drug-induced attack of bronchial asthma in inpatients: a 20-year survey of the Comprehensive Hospital Drug Monitoring Programme on adverse drug reactions, Berne/St. Gallen.
European journal of clinical pharmacology 1997;53;81-2 — 1997 — 81-2
Angioedema and acute asthma attack due to the unexpected occurrence of aspirin in an over-the-counter cold preparation.
The British journal of clinical practice 1996 Oct-Nov;50;412-3 — 1996 Oct-Nov — 412-3
Adverse pulmonary responses to aspirin and acetaminophen in chronic childhood asthma.
Pediatrics 1983 Mar;71;313-8 — 1983 Mar — 313-8
Aspirin-sensitive asthma.
Chest 1985 Mar;87;386-91 — 1985 Mar — 386-91
Aspirin-induced asthma: new insights into pathogenesis and clinical presentation of drug intolerance.
International archives of allergy and applied immunology 1989;90 Suppl 1;70-5 — 1989 — 70-5
Aspirin intolerance--a review.
Annals of allergy 1977 Jul;39;28-37 — 1977 Jul — 28-37