The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Cardiac- cardiorespiratory/pulmonary arrest
Publications
A Young Man with Accelerated Hyperthermia, Hypercapnia, and Profound Muscle Rigidity after Ingestion of a Weight Loss Agent.
Annals of the American Thoracic Society 2020 03;17;361-366 — 2020 03 — 361-366
Kamour A, George N, Gwynnette D, Cooper G, Lupton D, Eddleston M, Thompson JP, Vale JA, Thanacoody HK, Hill S, Thomas SH
Increasing frequency of severe clinical toxicity after use of 2,4-dinitrophenol in the UK: a report from the National Poisons Information Service.
Emergency medicine journal : EMJ 2015 May;32;383-6 — 2015 May — 383-6
Deliberate poisoning with dinitrophenol (DNP): an unlicensed weight loss pill.
Emergency medicine journal : EMJ 2010 Feb;27;159-60 — 2010 Feb — 159-60
Dinitrophenol in weight loss: the poison center and public health safety.
Veterinary and human toxicology 1986 Dec;28;574-5 — 1986 Dec — 574-5