The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XI.e

Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea

Publications

Cole JL

Acetazolamide Causes Worsening Acidosis in Uncompensated COPD Exacerbations: Increased Awareness Needed for Patient Safety.

The Journal of emergency medicine 2020 Mar 30;; — 2020 Mar 30

Adamson R, Swenson ER

Acetazolamide Use in Severe Chronic Obstructive Pulmonary Disease. Pros and Cons.

Annals of the American Thoracic Society 2017 Jul;14;1086-1093 — 2017 Jul — 1086-1093

Prieto de Paula JM, Franco Hidalgo S, Borge Gallardo L, Mayor Toranzo E

The importance of identifying the association between metabolic alkalosis and respiratory acidosis.

Archivos de bronconeumologia 2012 Feb;48;65-6 — 2012 Feb — 65-6

Heller I, Halevy J, Cohen S, Theodor E

Significant metabolic acidosis induced by acetazolamide. Not a rare complication.

Archives of internal medicine 1985 Oct;145;1815-7 — 1985 Oct — 1815-7

Sporn A, Scothorn DM, Terry JE

Metabolic acidosis induced by acetazolamide.

Journal of the American Optometric Association 1991 Dec;62;934-7 — 1991 Dec — 934-7