The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Death following exposure or poisoning
Publications
A Young Man with Accelerated Hyperthermia, Hypercapnia, and Profound Muscle Rigidity after Ingestion of a Weight Loss Agent.
Annals of the American Thoracic Society. 2020;17(3):361-366
Kamour A, George N, Gwynnette D, Cooper G, Lupton D, Eddleston M, Thompson JP, Vale JA, Thanacoody HK, Hill S, Thomas SH
Increasing frequency of severe clinical toxicity after use of 2,4-dinitrophenol in the UK: a report from the National Poisons Information Service.
Emergency medicine journal : EMJ. 2015;32(5):383-6
Toxicity of weight loss agents.
Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2012;8(2):145-52
Clinical features and treatment in patients with acute 2,4-dinitrophenol poisoning.
Journal of Zhejiang University. Science. B. 2011;12(3):189-92
2, 4-dinitrophenol poisoning caused by non-oral exposure.
Toxicology and industrial health. 2011;27(4):323-7
Deliberate poisoning with dinitrophenol (DNP): an unlicensed weight loss pill.
Emergency medicine journal : EMJ. 2010;27(2):159-60
Dying to be thin: a dinitrophenol related fatality.
Veterinary and human toxicology. 2004;46(5):251-4