The Drug-Induced Respiratory Disease Website and App

Dinitrophenol (2, 4-dinitrophenol or DNP)

Like aspirin, the chemical dInitrophenol uncouples oxidative phosphorylation. DNP is illegal as a weight-reducing drug. DNP can easily be purchased on the Internet. DNP poisoning is diagnosed on the basis of high fevers (up to 108°F or 42.2°C) that may disrupt enzyme systems, agitation and yellowish discoloration of skin, mucosa and internal organs. Target populations include bodybuilders, children and other persons who wish to loose weight (PMID 21739343)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic