The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Cardiomyopathy (acute, subacute, chronic)
Rare catecholamine-producing adrenal tumors may cause hypertrophic cardiomyopathy (PMID 30557989)
Publications
Cardiomyopathy after local infiltration or application of epinephrine for plastic surgery under general anesthesia : Two cases report.
Korean journal of anesthesiology 2009 Jun;56;725-728 — 2009 Jun — 725-728
Reversible catecholamine-induced cardiomyopathy by subcutaneous injections of epinephrine solution in an anesthetized patient.
Anesthesiology 2000 Feb;92;615-9 — 2000 Feb — 615-9